Osteopontin in Vascular Disease
نویسندگان
چکیده
منابع مشابه
Osteopontin: an emerging therapeutic target in uraemic vascular disease.
The incidence of cardiovascular disease remains high in the population with renal failure and constitutes the leadingcause ofmorbidity andmortality in these patients. According to the U.S. Renal Data System 2011 Annual Data Report, the rate of death among dialysis patients attributable to cardiovascular disease was 40% and 5% to acute myocardial infarction. However, the mechanisms by which rena...
متن کاملP 118: Osteopontin: An Early Player in Neuroinflammation Disease
Osteopontin also known as bone sialoprotein (BSP). Osteopontin role as a linking protein. it is an extracellular structural protein and therefore an organic component of bone. Osteoprontin (OPN) binds to several integrin receptors containing α4β1, α9β1, and α9β4 expressed by leukocytes. These receptors have been well-stable to function in cell adhesion, migratio...
متن کاملOsteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease.
Osteopontin (OPN) is a multifunctional molecule highly expressed in chronic inflammatory and autoimmune diseases, and it is specifically localized in and around inflammatory cells. OPN is a secreted adhesive molecule, and it is thought to aid in the recruitment of monocytes-macrophages and to regulate cytokine production in macrophages, dendritic cells, and T-cells. OPN has been classified as T...
متن کاملplasma osteopontin level in chronic liver disease and hepatocellular carcinoma
conclusions plasma opn is comparable to afp as a diagnostic marker and is related to the severity of liver involvement in hcc patients. plasma opn is of diagnostic potential value in nafld. background osteopontin (opn) is a secreted glycoprotein and is frequently associated with various tumors. objectives we sought to investigate the clinical usefulness of the level of plasma opn, compared to α...
متن کاملp 118: osteopontin: an early player in neuroinflammation disease
osteopontin also known as bone sialoprotein (bsp). osteopontin role as a linking protein. it is an extracellular structural protein and therefore an organic component of bone. osteoprontin (opn) binds to several integrin receptors containing α4β1, α9β1, and α9β4 expressed by leukocytes. these receptors have been well-stable to function in cell adhesion, migration, and survival in these cells. i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2019
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.118.311577